LYMPHOID NEOPLASIA Genome-wide homozygosity signatures and childhood acute lymphoblastic leukemia risk
نویسندگان
چکیده
1Section of Cancer Genetics, Institute of Cancer Research, Sutton; 2Yorkshire Regional Genetic Service and 3Department of Paediatric and Adolescent Oncology and Haematology, St James University Hospital, Leeds; 4Epidemiology and Genetics Unit, Department of Health Sciences, University of York, York; 5Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne; 6Cancer Immunogenetics Group, School of Cancer Sciences, University of Manchester, St Mary’s Hospital, Manchester; 7Molecular and Population Genetics, Wellcome Trust Centre for Human Genetics, Oxford; and 8Section of Haemato-oncology, Institute of Cancer Research, Sutton, United Kingdom
منابع مشابه
Genome-wide homozygosity signatures and childhood acute lymphoblastic leukemia risk.
Recent studies have reported that regions of homozygosity (ROH) in the genome are detectable in outbred populations and can be associated with an increased risk of malignancy. To examine whether homozygosity is associated with an increased risk of developing childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL), we analyzed 824 ALL cases and 2398 controls genotyped for 292 200 taggi...
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Acute lymphoblastic leukemia (ALL) is a malignant transformation and proliferation of lymphoid progenitor cells in bone marrow and blood, which is mainly found in children. Thiopurine methyltransferase (TPMT) is a thiopurine drug metabolizer enzyme that is prescribed for the treatment of ALL. Several single nucleotide polymorphisms in the TPMT gene have been reported to be associated with the d...
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تاریخ انتشار 2010